Bone Abstracts

The objective of the study was to investigate whether the anti-resorptive and bone-forming dual effect of Strontium Ranelate (SrR) influences the healing of a non-critical sized femoral mid-shaft bone defect.Sixty 16-weeks-old female Wistar rats were randomized into four groups. Cylindrical defects with a diameter of 2 mm was drilled through the anterior cortex of both right and left femoral mid-shafts. Two groups were treated with SrR (900 mg/kg/day) mi...

Most studies using botulinum toxin A (BTX) to achieve skeletal unloading use a study period of 3–4 weeks. The aim was to prolong this study time and to investigate the influence on the bone microstructure including the relationship between the thickness of horizontal and vertical trabeculae. Fifty-seven 16-week-old female Wistar rats were randomized into six Groups: Base; Ctrl 4w; and BTX4 4w; Ctrl 8w; BTX4 8w; BTX4+2 8w. The BTX animals were injected with 4 IU at baselin...